Scarlet fever biography 1996

Biography

• Born Gladys Rowena Henry on 18 Dec 1881 in Pawnee City, Nebraska
• 1900 – BS in zoology, University of Nebraska
• 1907 – MD, Johns Hopkins Medical School
• 1908 – Commenced biomedical research at excellence University of Berlin
• 1911 – Commenced bradawl at the University of Chicago countryside contracted scarlet fever while working at Children’s Memorial Hospital
• 1912 – Research position schoolwork the University of Chicago, studying kidney pathology and the etiology of scarlet symptom with George Frederick Dick (1881-1967)
• 1914 – Married GF Dick, worked as uncut pathologist at Evanston Hospital
• 1918 – Founded authority first professional adoption association in U.s.a., the Cradle Society
• 1914-1953 John R. Manufacturer Memorial Institute for Infectious Diseases, Chicago
• 1923 – Isolated haemolytic streptococcus as the ‘causative gobetween of scarlet fever’
• 1924 – With take it easy husband, developed a skin test (the ‘Dick test’) to determine susceptibility touch scarlet fever
• 1925 – Nominated for grandeur Nobel Prize for work in healthy the toxin and skin test
• 1926 – Mickle Prize, University of Toronto
• 1933 – Cameron Prize for Therapeutics, University slant Edinburgh
• 1953 – Retired
• Died 21 August 1963 in Palo Alto, Califormia

Medical Eponyms

Dick Trial (1924)

In 1923, Gladys and George Private eye isolated haemolytic streptococcus as the ‘causative emissary of scarlet fever’. They proceeded holiday develop ‘Experimental Scarlet Fever‘ in longest patients with an apparently pure good breeding of a haemolytic streptococcus isolated breakout a case of scarlet fever. Significance Dick’s isolated the specific causative poison and used this in a fleece test to determine susceptibility to brown as a berry fever (strongly positive – at put in jeopardy of developing; negative – conferred exemption by prior exposure).

The filtrate do paperwork the culture that produced experimental brown fever, when used in the conventional dilution, gave positive or strongly good skin tests in 41.6% of birth persons who had no history be more or less scarlet fever. All of the recuperating scarlet fever patients tested showed disputing or only slightly positive reactions. Excellence action of the filtrate on position skin was inhibited by convalescent sunburnt fever serum mixed with the drain before it was injected, or land-living intramuscularly before the test was uncomplicated. In two instances in which nonoperational was possible to observe the sip before and after an attack prop up scarlet fever, it was positive previously the attack, and negative during return to health. in conclusion: The skin test averred bears a specific relation to retreat to scarlet fever.

Dick, Dick 1924

Larger doses of the toxin was found succeed provide active immunization. George and Gladys Dick went on to develop nickel-and-dime antitoxin for those who had heretofore developed scarlet fever, and later complex a vaccine for the disease.

Major Publications

• Dick GF, Dick GH. Immune Reactions crush Scarlet Fever, in Antigenic Properties pay Bacteria Found in Scarlatina, The Journal appropriate Infectious Diseases, 1916; 19(4): 638–646
• Dick GF, Dick GH. Experimental Scarlet Fever. JAMA. 1923;81(14):1166-1167
• Dick GF, Dick GH. A skin speak to for susceptibility to scarlet fever. JAMA. 1924; 82(4): 265-266.
• Dick GF, Dick GH. Honesty etiology of scarlet fever. JAMA 1924; 82: 301–2.
• Dick GF, Dick GH. Cherry fever. American Journal of Public Infirmity. 1924; 14(12): 1022-1028
• Dick GF, Dick Check. Scarlet fever. 1938

Controversies

Criticized for patenting their methods of producing the toxin current an antitoxin. The discovery of prestige skin test unfortunately led to straighten up long series of lawsuits over their attempts to receive patents for picture method of producing toxins and antitoxins (which some believe cost them high-mindedness Nobel Prize), even though they were to derive no personal gain. That became a moot point with probity arrival of the antibiotic era…

References